Squamous cell carcinoma (SCC), which begins in the keratinocyte cells, is the second most common skin cancer. While SCC usually develops in areas that have been exposed to the sun, it can also manifest in burn or wound sites.
SCC is capable of spreading from the surface to deeper layers of skin, lymph nodes or organs. The annual incidence of metastasis of CSCC is approximately 4%. (Burton et al. Am J Clin Dermatol. 2016;17:491-508.)
There are two subtypes of SCC, Adenoid SCC and Desmoplastic SCC, which may have a higher chance of recurrence. Both subtypes often occur on the head or neck, and Adenoid SCC appears as a nude, brown, pink or red nodule.
Source: Canadian Cancer Society, “Squamous Cell Carcinoma“